Shiraz E-Medical Journal

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Hypogonadism and Associated Factors in Patients With HIV Infection Based on Total and Free Testosterone

Hossain Faramarzia 1 , Maryam Marzban 2 , Mahmood AminiLari 3 , * and Mesbah Shams 4
Authors Information
1 Department of Social Medicine, Shiraz University of Medical Sciences, Shiraz, IR Iran
2 Department of Public Health, Bushehr University of Medical Sciences, Bushehr, IR Iran
3 Shiraz HIV/AIDS Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran
4 Department of Internal Medicine and Endocrinology, Namazi Hospital, Endocrine and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran
Article information
  • Shiraz E-Medical Journal: January 01, 2014, 15 (1); e19734
  • Published Online: January 15, 2014
  • Article Type: Research Article
  • Received: November 5, 2013
  • Revised: December 15, 2013
  • Accepted: April 3, 2014
  • DOI: 10.17795/semj19734

To Cite: Faramarzia H, Marzban M, AminiLari M, Shams M. Hypogonadism and Associated Factors in Patients With HIV Infection Based on Total and Free Testosterone, Shiraz E-Med J. 2014 ; 15(1):e19734. doi: 10.17795/semj19734.

Copyright © 2014, Shiraz University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Materials and Methods
4. Results
5. Discussion
  • 1. Crum NF, Furtek KJ, Olson PE, Amling CL, Wallace MR. A review of hypogonadism and erectile dysfunction among HIV-infected men during the pre- and post-HAART eras: diagnosis, pathogenesis, and management. AIDS Patient Care STDS. 2005; 19(10): 655-71[DOI][PubMed]
  • 2. Petak SM, Baskin HJ, Bergman DA, Dickey RA, Nankin HA. AACE clinical practice guidelines for the evaluation and treatment of hypogonadism in adult male patients. Endocr Pract. 1996; 8(6): 440-53
  • 3. Dobs A. Role of testosterone in maintaining lean body mass and bone density in HIV-infected patients. Int J Impot Res. 2003; 15 Suppl 4-5[DOI][PubMed]
  • 4. Dobs AS, Dempsey MA, Ladenson PW, Frank PB. Endocrine disorders in men infected with human immunodeficiency virus. The American Journal of Medicine. 1988; 84(3): 611-6[DOI]
  • 5. Klein RS, Lo Y, Santoro N, Dobs AS. Androgen levels in older men who have or who are at risk of acquiring HIV infection. Clin Infect Dis. 2005; 41(12): 1794-803[DOI][PubMed]
  • 6. Roberson DW, Kosko DA. Men living with HIV and experiencing sexual dysfunction: an analysis of treatment options. J Assoc Nurses AIDS Care. 2013; 24(1 Suppl)-45[DOI][PubMed]
  • 7. Blick G. Optimal Diagnostic Measures and Thresholds for Hypogonadism in Men With HIV/AIDS: Comparison Between 2 Transdermal Testosterone Replacement Therapy Gels. Postgraduate Medicine. 2013; 125(2): 30-9[DOI]
  • 8. Engelson ES, Rabkin JG, Rabkin R, Kotler DP. Effects of Testosterone upon Body Composition. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 1996; 11(5): 510[DOI]
  • 9. Grinspoon SK, Bilezikian JP. HIV disease and the endocrine system. N Engl J Med. 1992; 327(19): 1360-5[DOI][PubMed]
  • 10. Rietschel P, Corcoran C, Stanley T, Basgoz N, Klibanski A, Grinspoon S. Prevalence of hypogonadism among men with weight loss related to human immunodeficiency virus infection who were receiving highly active antiretroviral therapy. Clin Infect Dis. 2000; 31(5): 1240-4[DOI][PubMed]
  • 11. Perez I, Moreno T, Navarro F, Santos J, Palacios R. Prevalence and factors associated with erectile dysfunction in a cohort of HIV-infected patients. Int J STD AIDS. 2013; 24(9): 712-5[DOI][PubMed]
  • 12. Amini Lari M, Parsa N, Marzban M, Shams M, Faramarzi H. Depression, Testosterone concentration, sexual dysfunction and methadone use among men with hypogonadism and HIV Infection. AIDS Behav. 2012; 16(8): 2236-43[DOI][PubMed]
  • 13. Laudat A, Blum L, Guechot J, Picard O, Cabane J, Imbert JC, et al. Changes in systemic gonadal and adrenal steroids in asymptomatic human immunodeficiency virus-infected men: relationship with the CD4 cell counts. Eur J Endocrinol. 1995; 133(4): 418-24[PubMed]
  • 14. Jain N, Mittal M, Tripathi A, Verma S, Dandu H, Gutch M. An observational study of endocrine disorders in HIV infected patients from north India. Journal of HIV and Human Reproduction. 2013; 1(1): 20[DOI]
  • 15. Radhakutty A, Wittert GT. Hypogonadism in men: how to evaluate and when to trea. MODeRn MeDICIn. 2013; 38(6): 47-50
  • 16. Collazos J, Esteban M. Has prolactin a role in the hypogonadal status of HIV-infected patients? J Int Assoc Physicians AIDS Care (Chic). 2009; 8(1): 43-6[DOI][PubMed]
  • 17. Cotter AG, Powderly WG. Endocrine complications of human immunodeficiency virus infection: hypogonadism, bone disease and tenofovir-related toxicity. Best Pract Res Clin Endocrinol Metab. 2011; 25(3): 501-15[DOI][PubMed]
  • 18. Iranian Ministry of Health. AIDS epidemic. 2013;
  • 19. Carnegie C. Diagnosis of hypogonadism: clinical assessments and laboratory tests. Rev Urol. 2004; 6 Suppl 6-8[PubMed]
  • 20. Moreno-Perez O, Escoin C, Serna-Candel C, Portilla J, Boix V, Alfayate R, et al. The determination of total testosterone and free testosterone (RIA) are not applicable to the evaluation of gonadal function in HIV-infected males. J Sex Med. 2010; 7(8): 2873-83[DOI][PubMed]
  • 21. Saad F, Haider A, Doros G, Traish A. Long-term treatment of hypogonadal men with testosterone produces substantial and sustained weight loss. Obesity (Silver Spring). 2013; 21(10): 1975-81[DOI][PubMed]
  • 22. de la Rosa RE, Hennessey JV. Hypogonadism and methadone: Hypothalamic hypogonadism after long-term use of high-dose methadone. Endocr Pract. 1996; 2(1): 4-7[DOI][PubMed]
  • 23. Sherman KE, Rouster SD, Chung RT, Rajicic N. Hepatitis C Virus prevalence among patients infected with Human Immunodeficiency Virus: a cross-sectional analysis of the US adult AIDS Clinical Trials Group. Clin Infect Dis. 2002; 34(6): 831-7[DOI][PubMed]
  • 24. Alavian SM, Adibi P, Zali MR. Hepatitis C virus in Iran: Epidemiology of an emerging infection. Arch Iranian Med. 2005; 8(2): 84-90
  • 25. Khani M, Vakili MM. Prevalence and risk factors of HIV, hepatitis B virus and hepatitis C virus infections in drug addicts among Zanjan prisoners. Arch Iranian Med. 2003; 6(1): 1-4
  • 26. Van Thiel DH, Lester R, Sherins RJ. Hypogonadism in alcoholic liver disease: evidence for a double defect. Gastroenterology. 1974; 67(6): 1188-99[PubMed]
  • 27. Crum-Cianflone NF, Bavaro M, Hale B, Amling C, Truett A, Brandt C, et al. Erectile dysfunction and hypogonadism among men with HIV. AIDS Patient Care STDS. 2007; 21(1): 9-19[DOI][PubMed]
  • 28. Carter JN, Tyson JE, Tolis G, Van Vliet S, Faiman C, Friesen HG. Prolactin-screening tumors and hypogonadism in 22 men. N Engl J Med. 1978; 299(16): 847-52[DOI][PubMed]
  • 29. Coviello AD, Kaplan B, Lakshman KM, Chen T, Singh AB, Bhasin S. Effects of graded doses of testosterone on erythropoiesis in healthy young and older men. J Clin Endocrinol Metab. 2008; 93(3): 914-9[DOI][PubMed]
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