Shiraz E-Medical Journal

Published by: Kowsar

Effects of Cucurbita ficifolia Intake on Type 2 Diabetes: Review of Current Evidences

Azade Bayat 1 , Zahra Jamali 1 , Hossein Hajianfar 1 and Motahar Heidari Beni 1 , *
Authors Information
1 Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, IR Iran
Article information
  • Shiraz E-Medical Journal: April 01, 2014, 15 (2); e20586
  • Published Online: April 20, 2014
  • Article Type: Review Article
  • Received: January 30, 2014
  • Accepted: March 3, 2014
  • DOI: 10.17795/semj20586

To Cite: Bayat A, Jamali Z, Hajianfar H, Heidari Beni M. Effects of Cucurbita ficifolia Intake on Type 2 Diabetes: Review of Current Evidences, Shiraz E-Med J. 2014 ; 15(2):e20586. doi: 10.17795/semj20586.

Copyright © 2014, Shiraz University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Context
2. Evidence Acquisition
3. Results
4. Discussion
5. Conclusions
  • 1. Zhang TT, Jiang JG. Active ingredients of traditional Chinese medicine in the treatment of diabetes and diabetic complications. Expert Opin Investig Drugs. 2012; 21(11): 1625-42[DOI][PubMed]
  • 2. Kaushik G, Satya S, Khandelwal RK, Naik SN. Commonly consumed Indian plant food materials in the management of diabetes mellitus. Diabetes Metab Synd Clin Res Rev. 2010; 4(1): 21-40
  • 3. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004; 27(5): 1047-53[PubMed]
  • 4. Liu Y, Jin H, Xu ZQ, Nan WK, Wang T, Cheng YY. [Effects of pumpkin polysaccharides on blood glucose and blood lipids in diabetic rats]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2006; 22(3): 358-61[PubMed]
  • 5. Alfawaz MA. Chemical composition and oil characteristics of pumpkin (Cucurbita maxima) seed kernels. Res Bul Food Sci and Agric Center, King Saud Univ. 2004; 129: 5-18
  • 6. Acosta-Patino JL, Jimenez-Balderas E, Juarez-Oropeza MA, Diaz-Zagoya JC. Hypoglycemic action of Cucurbita ficifolia on Type 2 diabetic patients with moderately high blood glucose levels. J Ethnopharmacol. 2001; 77(1): 99-101[PubMed]
  • 7. Chen JG, Liu ZQ, Wang Y, Lai WQ, Mei S, Fu Y, et al. Effects of sugar-removed pumpkin zymotic powders in preventing and treating the increase of blood glucose in alloxan-induced diabetic mice. Diabetes Complicat. 2005; 4(2): 94-5
  • 8. Makni M, Fetoui H, Gargouri NK, Garoui el M, Zeghal N. Antidiabetic effect of flax and pumpkin seed mixture powder: effect on hyperlipidemia and antioxidant status in alloxan diabetic rats. J Diabetes Complications. 2011; 25(5): 339-45[DOI][PubMed]
  • 9. Diaz-Flores M, Angeles-Mejia S, Baiza-Gutman LA, Medina-Navarro R, Hernandez-Saavedra D, Ortega-Camarillo C, et al. Effect of an aqueous extract of Cucurbita ficifolia Bouche on the glutathione redox cycle in mice with STZ-induced diabetes. J Ethnopharmacol. 2012; 144(1): 101-8[DOI][PubMed]
  • 10. Xia T, Wang Q. Hypoglycaemic role of Cucurbita ficifolia (Cucurbitaceae) fruit extract in streptozotocin‐induced diabetic rats. J Sci Food Agric. 2007; 87(9): 1753-7
  • 11. Yadav M, Jain S, Tomar R, Prasad GB, Yadav H. Medicinal and biological potential of pumpkin: an updated review. Nutr Res Rev. 2010; 23(2): 184-90[DOI][PubMed]
  • 12. Adams GG, Imran S, Wang S, Mohammad A, Kok S, Gray DA, et al. The hypoglycaemic effect of pumpkins as anti-diabetic and functional medicines. Food Res Int. 2011; 44(4): 862-7
  • 13. Alarcon-Aguilar FJ, Hernandez-Galicia E, Campos-Sepulveda AE, Xolalpa-Molina S, Rivas-Vilchis JF, Vazquez-Carrillo LI, et al. Evaluation of the hypoglycemic effect of Cucurbita ficifolia Bouche (Cucurbitaceae) in different experimental models. J Ethnopharmacol. 2002; 82(2-3): 185-9[PubMed]
  • 14. Dixit Y, Kar A. Protective role of three vegetable peels in alloxan induced diabetes mellitus in male mice. Plant Foods Hum Nutr. 2010; 65(3): 284-9[DOI][PubMed]
  • 15. Jiang Z, Du Q. Glucose-lowering activity of novel tetrasaccharide glyceroglycolipids from the fruits of Cucurbita moschata. Bioorg Med Chem Lett. 2011; 21(3): 1001-3[DOI][PubMed]
  • 16. Teugwa CM, Boudjeko T, Tchinda BT, Mejiato PC, Zofou D. Anti-hyperglycaemic globulins from selected Cucurbitaceae seeds used as antidiabetic medicinal plants in Africa. BMC Complement Altern Med. 2013; 13: 63[DOI][PubMed]
  • 17. Yoshinari O, Sato H, Igarashi K. Anti-diabetic effects of pumpkin and its components, trigonelline and nicotinic acid, on Goto-Kakizaki rats. Biosci Biotechnol Biochem. 2009; 73(5): 1033-41[PubMed]
  • 18. Quanhong L, Caili F, Yukui R, Guanghui H, Tongyi C. Effects of protein-bound polysaccharide isolated from pumpkin on insulin in diabetic rats. Plant Foods Hum Nutr. 2005; 60(1): 13-6[PubMed]
  • 19. Asgary S, Moshtaghian SJ, Setorki M, Kazemi. S., Rafieian-kopaei M, Adelnia A, et al. Hypoglycaemic and hypolipidemic effects of pumpkin (Cucurbita pepo L.) on alloxan-induced diabetic rats. Afr J Pharm Pharmacol. 2011; 5(23): 2620-6
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments