Shiraz E-Medical Journal

Published by: Kowsar

Phytochemicals and Hypertension

Akram Kooshki 1 and BiBi Leila Hoseini 1 , *
Authors Information
1 Department of Biochemistry and Nutrition, Sabzevar University of Medical Sciences, Sabzevar, IR Iran
Article information
  • Shiraz E-Medical Journal: January 01, 2014, 15 (1); e19738
  • Published Online: January 15, 2014
  • Article Type: Review Article
  • Received: November 8, 2013
  • Revised: December 10, 2013
  • Accepted: January 10, 2014
  • DOI: 10.17795/semj19738

To Cite: Kooshki A, Hoseini B L. Phytochemicals and Hypertension, Shiraz E-Med J. 2014 ; 15(1):e19738. doi: 10.17795/semj19738.

Copyright © 2014, Shiraz University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Context
2. Evidence Acquisition
3. Results
4. Discussion
  • 1. Ranjbar F, Akbarzade F, khaneshi M. The study oftype A personality in essential Hypertensionpatient. Medical Journal of Kordestan Universityof Medical Sciences . 2006; 11: 26-31
  • 2. Kooshki A, Yaghoubifar MA, Behnam VHR. Relation between drinking water and blood pressure. Sabzevar J Medical Science. 2004; 10(3): 23-8
  • 3. Kooshki A, Mohajeri N, Movahedi A. Prevalence of CVD Risk Factors related to diet in Patients Referring toModarres Hospital in Tehran in 1999. Sabzevar J Medical Science. 2004; 10(2): 17-22
  • 4. Liu S, Manson JE, Lee IM, Cole SR, Hennekens CH, Willett WC, et al. Fruit and vegetable intake and risk of cardiovascular disease: the Women's Health Study. Am J Clin Nutr. 2000; 72(4): 922-8[PubMed]
  • 5. de Paula TP, Steemburgo T, de Almeida JC, Dall'Alba V, Gross JL, de Azevedo MJ. The role of Dietary Approaches to Stop Hypertension (DASH) diet food groups in blood pressure in type 2 diabetes. Br J Nutr. 2012; 108(1): 155-62[DOI][PubMed]
  • 6. Alonso A, de la Fuente C, Martin-Arnau AM, de Irala J, Martinez JA, Martinez-Gonzalez MA. Fruit and vegetable consumption is inversely associated with blood pressure in a Mediterranean population with a high vegetable-fat intake: the Seguimiento Universidad de Navarra (SUN) Study. Br J Nutr. 2004; 92(2): 311-9[DOI][PubMed]
  • 7. Wang L, Manson JE, Gaziano JM, Buring JE, Sesso HD. Fruit and Vegetable Intake and the Risk of Hypertension in Middle-Aged and Older Women. American Journal of Hypertension. 2012; 25(2): 180-9[DOI]
  • 8. Kooshki A, Golafrooz Shahri M. Assessment of macro and micro nutrients on blood pressure in diabetics patients. Ofogh Danesh. 2004; 11(1): 34-7
  • 9. Kooshki A, Aminpour A, Azar M, Kalantari N, Ardakani H. The effect of drinking damavand mineral water on sodium,potassium, magnesium and calcium cations in men with hpertension. . Sabzevar J Medical Science . 2003; 9(4): 31-8
  • 10. Kooshki A, Aminpour A, Azar M. Influence of type and duration of water intake on blood pressure in hypertensive men. Ofogh Danesh . 2007; 12(2): 50-4
  • 11. Yang YC, Lu FH, Wu JS, Wu CH, Chang CJ. The protective effect of habitual tea consumption on hypertension. Arch Intern Med. 2004; 164(14): 1534-40[DOI][PubMed]
  • 12. Giday A, Tadesse B. Prevalence and determinants of hypertension in rural and urban areas of southern Ethiopia. Ethiop Med J. 2011; 49(2): 139-47[PubMed]
  • 13. Sae-tan S, Grove KA, Lambert JD. Weight control and prevention of metabolic syndrome by green tea. Pharmacol Res. 2011; 64(2): 146-54[DOI][PubMed]
  • 14. Kurita I, Maeda-Yamamoto M, Tachibana H, Kamei M. Antihypertensive effect of Benifuuki tea containing O-methylated EGCG. J Agric Food Chem. 2010; 58(3): 1903-8[DOI][PubMed]
  • 15. Dauchet L, Amouyel P, Hercberg S, Dallongeville J. Fruit and vegetable consumption and risk of coronary heart disease: a meta-analysis of cohort studies. J Nutr. 2006; 136(10): 2588-93[PubMed]
  • 16. Seymour EM, Singer AA, Bennink MR, Parikh RV, Kirakosyan A, Kaufman PB, et al. Chronic intake of a phytochemical-enriched diet reduces cardiac fibrosis and diastolic dysfunction caused by prolonged salt-sensitive hypertension. J Gerontol A Biol Sci Med Sci. 2008; 63(10): 1034-42[PubMed]
  • 17. Melby MK, Murashima M, Watanabe S. Phytochemical intake and relationship to past health history in Japanese women. Biofactors. 2004; 22(1-4): 265-9[PubMed]
  • 18. Moline J, Bukharovich IF, Wolff MS, Phillips R. Dietary flavonoids and hypertension: is there a link? Med Hypotheses. 2000; 55(4): 306-9[DOI][PubMed]
  • 19. Cassidy A, O'Reilly EJ, Kay C, Sampson L, Franz M, Forman JP, et al. Habitual intake of flavonoid subclasses and incident hypertension in adults. Am J Clin Nutr. 2011; 93(2): 338-47[DOI][PubMed]
  • 20. Jouad H, Lacaille-Dubois MA, Lyoussi B, Eddouks M. Effects of the flavonoids extracted from Spergularia purpurea Pers. on arterial blood pressure and renal function in normal and hypertensive rats. Journal of Ethnopharmacology. 2001; 76(2): 159-63[DOI]
  • 21. Schini-Kerth VB, Auger C, Etienne-Selloum N, Chataigneau T. Polyphenol-induced endothelium-dependent relaxations role of NO and EDHF. Adv Pharmacol. 2010; 60: 133-75[DOI][PubMed]
  • 22. Stoclet JC, Chataigneau T, Ndiaye M, Oak MH, El Bedoui J, Chataigneau M, et al. Vascular protection by dietary polyphenols. Eur J Pharmacol. 2004; 500(1-3): 299-313[DOI][PubMed]
  • 23. Nicholson SK, Tucker GA, Brameld JM. Effects of dietary polyphenols on gene expression in human vascular endothelial cells. Proc Nutr Soc. 2008; 67(1): 42-7[DOI][PubMed]
  • 24. Medina-Remon A, Zamora-Ros R, Rotches-Ribalta M, Andres-Lacueva C, Martinez-Gonzalez MA, Covas MI, et al. Total polyphenol excretion and blood pressure in subjects at high cardiovascular risk. Nutr Metab Cardiovasc Dis. 2011; 21(5): 323-31[DOI][PubMed]
  • 25. Ghosh D, Scheepens A. Vascular action of polyphenols. Mol Nutr Food Res. 2009; 53(3): 322-31[DOI][PubMed]
  • 26. Mennen LI, Sapinho D, Ito H, Bertrais S, Galan P, Hercberg S, et al. Urinary flavonoids and phenolic acids as biomarkers of intake for polyphenol-rich foods. Br J Nutr. 2006; 96(1): 191-8[PubMed]
  • 27. Suzuki A, Fujii A, Yamamoto N, Yamamoto M, Ohminami H, Kameyama A, et al. Improvement of hypertension and vascular dysfunction by hydroxyhydroquinone-free coffee in a genetic model of hypertension. FEBS Lett. 2006; 580(9): 2317-22[DOI][PubMed]
  • 28. Zhao Y, Wang J, Ballevre O, Luo H, Zhang W. Antihypertensive effects and mechanisms of chlorogenic acids. Hypertension Research. 2011; 35(4): 370-4[DOI]
  • 29. Grassi D, Desideri G, Necozione S, Lippi C, Casale R, Properzi G, et al. Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate. J Nutr. 2008; 138(9): 1671-6[PubMed]
  • 30. Monroy-Ruiz J, Sevilla MA, Carron R, Montero MJ. Astaxanthin-enriched-diet reduces blood pressure and improves cardiovascular parameters in spontaneously hypertensive rats. Pharmacol Res. 2011; 63(1): 44-50[DOI][PubMed]
  • 31. Kooshki A, Golafrooz Shahri M. Relationship between carotenoid intake and serum suger and lipids in diabetics type 2 patients. Ardebil J Med Scien. 2007; 6(3): 287-9
  • 32. Tapiero H, Townsend DM, Tew KD. The role of carotenoids in the prevention of human pathologies. Biomed Pharmacother. 2004; 58(2): 100-10[DOI][PubMed]
  • 33. Paran E, Novack V, Engelhard YN, Hazan-Halevy I. The effects of natural antioxidants from tomato extract in treated but uncontrolled hypertensive patients. Cardiovasc Drugs Ther. 2009; 23(2): 145-51[DOI][PubMed]
  • 34. Ried K, Fakler P. Protective effect of lycopene on serum cholesterol and blood pressure: Meta-analyses of intervention trials. Maturitas. 2011; 68(4): 299-310[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .
Readers' Comments