Shiraz E-Medical Journal

Published by: Kowsar

Elevated Serum Interleukin-23 and Interleukin-6 Levels in Schizophrenic Patients Compared to Those in Healthy Controls

Ali Shahraki 1 , * , Roodabe Sarabandi 2 , Mohsen Kianpour 3 and Zahra Zakeri 4
Authors Information
1 Department of Biology, Faculty of Science, University of Sistan and Baluchestan, Zahedan, IR Iran
2 Department of Biology, Isfahan Payame Noor University, Isfahan, IR Iran
3 Department of Neurology, Zahedan University of Medical Sciences, Zahedan, IR Iran
4 Department of Internal Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran
Article information
  • Shiraz E-Medical Journal: June 01, 2016, 17 (6); e38984
  • Published Online: June 25, 2016
  • Article Type: Research Article
  • Received: May 5, 2016
  • Revised: June 1, 2016
  • Accepted: June 2, 2016
  • DOI: 10.17795/semj38984

To Cite: Shahraki A, Sarabandi R, Kianpour M, Zakeri Z. Elevated Serum Interleukin-23 and Interleukin-6 Levels in Schizophrenic Patients Compared to Those in Healthy Controls, Shiraz E-Med J. 2016 ; 17(6):e38984. doi: 10.17795/semj38984.

Abstract
Copyright © 2016, Shiraz University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Muller N, Schwarz MJ. Role of cytokine network in major psychoses. Advance Mol and Cell Biol. 2003; 31: 999-1031
  • 2. Drzyzga L, Obuchowicz E, Marcinowska A, Herman ZS. Cytokines in schizophrenia and the effects of antipsychotic drugs. Brain Behav Immun. 2006; 20(6): 532-45[DOI][PubMed]
  • 3. Khairova RA, Machado-Vieira R, Du J, Manji HK. A potential role for pro-inflammatory cytokines in regulating synaptic plasticity in major depressive disorder. Int J Neuropsychopharmacol. 2009; 12(4): 561-78[DOI][PubMed]
  • 4. Goldsmith DR, Rapaport MH, Miller BJ. A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression. Mol Psychiatry. 2016; [DOI][PubMed]
  • 5. Noto CS, Gadelha A, Belangero SI, Smith MA, de Aguiar BW, Panizzuti B, et al. Association of biomarkers and depressive symptoms in schizophrenia. Neurosci Lett. 2011; 505(3): 282-5[DOI][PubMed]
  • 6. Bedrossian N, Haidar M, Fares J, Kobeissy FH, Fares Y. Inflammation and Elevation of Interleukin-12p40 in Patients with Schizophrenia. Front Mol Neurosci. 2016; 9: 16[DOI][PubMed]
  • 7. Kirkpatrick B, Miller BJ. Inflammation and schizophrenia. Schiz Bulletin. 2013;
  • 8. Ajami A, Abedian F, Hamzeh Hosseini S, Akbarian E, Alizadeh-Navaei R, Taghipour M. Serum TNF-alpha, IL-10 and IL-2 in schizophrenic patients before and after treatment with risperidone and clozapine. Iran J Immunol. 2014; 11(3): 200-9[PubMed]
  • 9. Henneberg AE, Horter S, Ruffert S. Increased prevalence of antibrain antibodies in the sera from schizophrenic patients. Schizophr Res. 1994; 14(1): 15-22[PubMed]
  • 10. Muller N, Schwarz MJ. Cytokines, Immunity and schizophrenia with emphasis on underlying neurochemical mechanisms. In: Siegel A., And Zalcman SS. The neuroimmunological basis of behavior and mental disorders. . Springer Science Business Media. 2009; : 307-25
  • 11. Nawa H, Takahashi M, Patterson PH. Cytokine and growth factor involvement in schizophrenia--support for the developmental model. Mol Psychiatry. 2000; 5(6): 594-603[PubMed]
  • 12. Aggarwal S, Ghilardi N, Xie MH, de Sauvage FJ, Gurney AL. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem. 2003; 278(3): 1910-4[DOI][PubMed]
  • 13. Bettelli E, Kuchroo VK. IL-12- and IL-23-induced T helper cell subsets: birds of the same feather flock together. J Exp Med. 2005; 201(2): 169-71[DOI][PubMed]
  • 14. Delaney WE. Sounds of trumpets and other jazz. Sunderman Awards address. Ann Clin Lab Sci. 1975; 5(1): 1-3[PubMed]
  • 15. Hunter CA. New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions. Nat Rev Immunol. 2005; 5(7): 521-31[DOI][PubMed]
  • 16. Muller N, Schwarz MJ. Role of cytokine network in major psychoses. Advance Mol and Cell Biol. 2004; 31: 999-1031
  • 17. Schwieler L, Larsson MK, Skogh E, Kegel ME, Orhan F, Abdelmoaty S, et al. Increased levels of IL-6 in the cerebrospinal fluid of patients with chronic schizophrenia--significance for activation of the kynurenine pathway. J Psychiatry Neurosci. 2015; 40(2): 126-33[PubMed]
  • 18. Kuloglu M, Bayik Y, Unal A, Gecici O, Ustundag B. Serum IL-1β, IL-2, IL-6, and IL-8 levels in schizophrenia subtypes. Bull Clin Psychpharmacol. 2011; 21: 193-200
  • 19. Cazzullo CL, Scarone S, Grassi B, Vismara C, Trabattoni D, Clerici M, et al. Cytokines production in chronic schizophrenia patients with or without paranoid behaviour. Prog Neuropsychopharmacol Biol Psychiatry. 1998; 22(6): 947-57[PubMed]
  • 20. Cua DJ, Sherlock J, Chen Y, Murphy CA, Joyce B, Seymour B, et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature. 2003; 421(6924): 744-8[DOI][PubMed]
  • 21. Li Y, Chu N, Hu A, Gran B, Rostami A, Zhang GX. Inducible IL-23p19 expression in human microglia via p38 MAPK and NF-kappaB signal pathways. Exp Mol Pathol. 2008; 84(1): 1-8[DOI][PubMed]
  • 22. Tang C, Chen S, Qian H, Huang W. Interleukin-23: as a drug target for autoimmune inflammatory diseases. Immunology. 2012; 135(2): 112-24[DOI][PubMed]
  • 23. Rapaport MH, Delrahim KK. An abbreviated review of immune abnormalities in schizophrenia. CNS Spectr. 2001; 6(5): 392-7[PubMed]
  • 24. Strous RD, Shoenfeld Y. Schizophrenia, autoimmunity and immune system dysregulation: a comprehensive model updated and revisited. J Autoimmun. 2006; 27(2): 71-80[DOI][PubMed]
  • 25. Gilvarry CM, Sham PC, Jones PB, Cannon M, Wright P, Lewis SW, et al. Family history of autoimmune diseases in psychosis. Schizophr Res. 1996; 19(1): 33-40[PubMed]
  • 26. Aberg KA, Liu Y, Bukszar J, McClay JL, Khachane AN, Andreassen OA, et al. A comprehensive family-based replication study of schizophrenia genes. JAMA Psychiatry. 2013; 70(6): 573-81[DOI][PubMed]
  • 27. Muller N, Ackenheil M. Psychoneuroimmunology and the cytokine action in the CNS: implications for psychiatric disorders. Prog Neuropsychopharmacol Biol Psychiatry. 1998; 22(1): 1-33[PubMed]
  • 28. Shahraki A, Kianpour M, Sarabandi R, Kordi DM. Evaluation of serum interleukin-23 and interleukin-6 in schizophrenic patients versus healthy control subjects. 4th Con the Medit Neurosci Soc. 2012; : 153
  • 29. O'Connell KE, Thakore J, Dev KK. Increased interleukin 23 (IL23) levels in schizophrenia patients treated with depot antipsychotic medication. Cytokine. 2015; 73(1): 196-8[DOI][PubMed]
  • 30. Fillman SG, Cloonan N, Catts VS, Miller LC, Wong J, McCrossin T, et al. Increased inflammatory markers identified in the dorsolateral prefrontal cortex of individuals with schizophrenia. Mol Psychiatry. 2013; 18(2): 206-14[DOI][PubMed]
  • 31. O'Connell KE, Thakore J, Dev KK. Pro-inflammatory cytokine levels are raised in female schizophrenia patients treated with clozapine. Schizophr Res. 2014; 156(1): 1-8[DOI][PubMed]
  • 32. O'Connell K, Thakore J, Dev KK. Levels of S100B are raised in female patients with schizophrenia. BMC Psychiatry. 2013; 13: 146[DOI][PubMed]
  • 33. Frydecka D, Misiak B, Pawlak-Adamska E, Karabon L, Tomkiewicz A, Sedlaczek P, et al. Interleukin-6: the missing element of the neurocognitive deterioration in schizophrenia? The focus on genetic underpinnings, cognitive impairment and clinical manifestation. Eur Arch Pschiat Clin Neurosci. 2015; 265: 449-59
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments