Shiraz E-Medical Journal

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Resistin In Systemic Lupus Erythematosus: Correlation with Disease Activity and Inflammatory Markers

Zahra Rezaieyazdi 1 , Nastaran Hashemi 1 , Zahra Mirfeizi 1 , * , Maryam Sahebari 1 and Narges Hashemi 2
Authors Information
1 Rheumatic Diseases Research Center, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2 Pediatrician Departments, Birjand University of Medical Sciences, Birjand, Iran
Article information
  • Shiraz E-Medical Journal: February 01, 2017, 18 (2); e43376
  • Published Online: January 18, 2017
  • Article Type: Research Article
  • Received: October 26, 2016
  • Revised: January 9, 2017
  • Accepted: January 14, 2017
  • DOI: 10.17795/semj43376

To Cite: Rezaieyazdi Z, Hashemi N, Mirfeizi Z, Sahebari M, Hashemi N. Resistin In Systemic Lupus Erythematosus: Correlation with Disease Activity and Inflammatory Markers, Shiraz E-Med J. 2017 ; 18(2):e43376. doi: 10.17795/semj43376.

Abstract
Copyright © 2017, Shiraz University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Methods
3. Results
4. Discussion
Acknowledgements
Footnote
References
  • 1. Tilg H, Moschen AR. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol. 2006; 6(10): 772-83[DOI][PubMed]
  • 2. Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature. 2001; 414(6865): 799-806[DOI][PubMed]
  • 3. Cinti S, Mitchell G, Barbatelli G, Murano I, Ceresi E, Faloia E, et al. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res. 2005; 46(11): 2347-55[DOI][PubMed]
  • 4. Steppan CM, Lazar MA. The current biology of resistin. J Intern Med. 2004; 255(4): 439-47[DOI][PubMed]
  • 5. Reilly MP, Lehrke M, Wolfe ML, Rohatgi A, Lazar MA, Rader DJ. Resistin is an inflammatory marker of atherosclerosis in humans. Circulation. 2005; 111(7): 932-9[DOI][PubMed]
  • 6. Fujinami A, Obayashi H, Ohta K, Ichimura T, Nishimura M, Matsui H, et al. Enzyme-linked immunosorbent assay for circulating human resistin: resistin concentrations in normal subjects and patients with type 2 diabetes. Clin Chim Acta. 2004; 339(1-2): 57-63[DOI]
  • 7. Vozarova de Courten B, Degawa-Yamauchi M, Considine RV, Tataranni PA. High serum resistin is associated with an increase in adiposity but not a worsening of insulin resistance in Pima Indians. Diabetes. 2004; 53(5): 1279-84[DOI][PubMed]
  • 8. Silha JV, Murphy LJ. Serum resistin (FIZZ3) protein is increased in obese humans. J Clin Endocrinol Metab. 2004; 89(4): 1977-8[DOI][PubMed]
  • 9. Heilbronn LK, Rood J, Janderova L, Albu JB, Kelley DE, Ravussin E, et al. Relationship between serum resistin concentrations and insulin resistance in nonobese, obese, and obese diabetic subjects. J Clin Endocrinol Metab. 2004; 89(4): 1844-8[DOI][PubMed]
  • 10. Lee JH, Chan JL, Yiannakouris N, Kontogianni M, Estrada E, Seip R, et al. Circulating resistin levels are not associated with obesity or insulin resistance in humans and are not regulated by fasting or leptin administration: cross-sectional and interventional studies in normal, insulin-resistant, and diabetic subjects. J Clin Endocrinol Metab. 2003; 88(10): 4848-56[DOI][PubMed]
  • 11. Youn BS, Yu KY, Park HJ, Lee NS, Min SS, Youn MY, et al. Plasma resistin concentrations measured by enzyme-linked immunosorbent assay using a newly developed monoclonal antibody are elevated in individuals with type 2 diabetes mellitus. J Clin Endocrinol Metab. 2004; 89(1): 150-6[DOI][PubMed]
  • 12. Silha JV, Krsek M, Skrha JV, Sucharda P, Nyomba BL, Murphy LJ. Plasma resistin, adiponectin and leptin levels in lean and obese subjects: correlations with insulin resistance. Eur J Endocrinol. 2003; 149(4): 331-5[DOI][PubMed]
  • 13. Bajaj M, Suraamornkul S, Hardies LJ, Pratipanawatr T, DeFronzo RA. Plasma resistin concentration, hepatic fat content, and hepatic and peripheral insulin resistance in pioglitazone-treated type II diabetic patients. Int J Obes Relat Metab Disord. 2004; 28(6): 783-9[DOI][PubMed]
  • 14. Patel L, Buckels AC, Kinghorn IJ, Murdock PR, Holbrook JD, Plumpton C, et al. Resistin is expressed in human macrophages and directly regulated by PPAR gamma activators. Biochem Biophys Res Commun. 2003; 300(2): 472-6[DOI][PubMed]
  • 15. Nagaev I, Bokarewa M, Tarkowski A, Smith U. Human resistin is a systemic immune-derived proinflammatory cytokine targeting both leukocytes and adipocytes. PLoS One. 2006; 1: 31[DOI][PubMed]
  • 16. Bokarewa M, Nagaev I, Dahlberg L, Smith U, Tarkowski A. Resistin, an adipokine with potent proinflammatory properties. J Immunol. 2005; 174(9): 5789-95[DOI][PubMed]
  • 17. Almehed K, d'Elia HF, Bokarewa M, Carlsten H. Role of resistin as a marker of inflammation in systemic lupus erythematosus. Arthritis Res Ther. 2008; 10(1)[DOI][PubMed]
  • 18. Chung CP, Long AG, Solus JF, Rho YH, Oeser A, Raggi P, et al. Adipocytokines in systemic lupus erythematosus: relationship to inflammation, insulin resistance and coronary atherosclerosis. Lupus. 2009; 18(9): 799-806[DOI][PubMed]
  • 19. Karmiris K, Koutroubakis IE, Xidakis C, Polychronaki M, Voudouri T, Kouroumalis EA. Circulating levels of leptin, adiponectin, resistin, and ghrelin in inflammatory bowel disease. Inflamm Bowel Dis. 2006; 12(2): 100-5[DOI][PubMed]
  • 20. Migita K, Maeda Y, Miyashita T, Kimura H, Nakamura M, Ishibashi H, et al. The serum levels of resistin in rheumatoid arthritis patients. Clin Exp Rheumatol. 2006; 24(6): 698-701[PubMed]
  • 21. Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982; 25(11): 1271-7[DOI][PubMed]
  • 22. Bombardier C, Gladman DD, Urowitz MB, Caron D, Chang CH. Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE. Arthritis Rheum. 1992; 35(6): 630-40[DOI][PubMed]
  • 23. Vadacca M, Margiotta D, Rigon A, Cacciapaglia F, Coppolino G, Amoroso A, et al. Adipokines and systemic lupus erythematosus: relationship with metabolic syndrome and cardiovascular disease risk factors. J Rheumatol. 2009; 36(2): 295-7[DOI][PubMed]
  • 24. De Sanctis JB, Zabaleta M, Bianco NE, Garmendia JV, Rivas L. Serum adipokine levels in patients with systemic lupus erythematosus. Autoimmunity. 2009; 42(4): 272-4[DOI][PubMed]
  • 25. LunFei L, JianYou W, LiMin L, YueLan C, Min Z. Insulin resistance and serum resistin levels in patients with systemic lupus erythematosus. Chin J Dermatol. 2009; 42(9): 593-5
  • 26. Kunnari A, Ukkola O, Paivansalo M, Kesaniemi YA. High plasma resistin level is associated with enhanced highly sensitive C-reactive protein and leukocytes. J Clin Endocrinol Metab. 2006; 91(7): 2755-60[DOI][PubMed]
  • 27. Sabry A, Sheashaa H, El-Husseini A, Mahmoud K, Eldahshan KF, George SK, et al. Proinflammatory cytokines (TNF-alpha and IL-6) in Egyptian patients with SLE: its correlation with disease activity. Cytokine. 2006; 35(3-4): 148-53[DOI][PubMed]
  • 28. Aruna B, Ghosh S, Singh AK, Mande SC, Srinivas V, Chauhan R, et al. Human recombinant resistin protein displays a tendency to aggregate by forming intermolecular disulfide linkages. Biochemistry. 2003; 42(36): 10554-9[DOI][PubMed]
  • 29. Elshishtawy H, Ibrahim S, Helmi A, Farouk N, Elshinnawy MA. Resistin in systemic lupus erythematosus: Relation to lupus nephritis and premature atherosclerosis. Eg Rheumatol. 2012; 34(4): 137-46[DOI]
  • 30. Baker JF, Morales M, Qatanani M, Cucchiara A, Nackos E, Lazar MA, et al. Resistin levels in lupus and associations with disease-specific measures, insulin resistance, and coronary calcification. J Rheumatol. 2011; 38(11): 2369-75[DOI][PubMed]
  • 31. Hutcheson J, Ye Y, Han J, Arriens C, Saxena R, Li QZ, et al. Resistin as a potential marker of renal disease in lupus nephritis. Clin Exp Immunol. 2015; 179(3): 435-43[DOI][PubMed]
  • 32. Sharifipour F, Zeraati A, Sahebari M, Hatef M, Naghibi M, Rezaieyazdi Z, et al. Association of urinary lipocalin-2 with lupus nephritis. Iran J Basic Med Sci. 2013; 16(9): 1011-5[PubMed]
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