Shiraz E-Medical Journal

Published by: Kowsar

Haloperidol Adjunct With Morphine on Postoperative Pain Management in Opioid-Addicted Patients Undergoing Orthopedic Surgery

Asif Parviz Kazemi 1 , Tahere Jowkar 2 , * , Afshin Amini 1 and Seyed Taghi Heydari 3
Authors Information
1 Department of Anesthesiology, Shiraz University of Medical Sciences, Shiraz, IR Iran
2 Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, IR Iran
3 Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran
Article information
  • Shiraz E-Medical Journal: October 2015, 16 (9-10); e59892
  • Published Online: September 30, 2015
  • Article Type: Research Article
  • Received: June 10, 2015
  • Revised: August 23, 2015
  • Accepted: August 26, 2015
  • DOI: 10.17795/semj30625

To Cite: Kazemi A P, Jowkar T, Amini A, Heydari S T. Haloperidol Adjunct With Morphine on Postoperative Pain Management in Opioid-Addicted Patients Undergoing Orthopedic Surgery, Shiraz E-Med J. 2015 ; 16(9-10):e59892. doi: 10.17795/semj30625.

Abstract
Copyright © 2015, Shiraz University of Medical Sciences.This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Javid MJ, Ghanbar M, Shahidi A, Golbabaii SH, Atashkhoii S, Shahrokhi SH. Advantages of buprenorphine in comparison to morphine in postoperative pain control. Shiraz E Med J. 2008; 9(3): 129-33
  • 2. Imantalab V, Mirmansouri A, Sedighinejad A, Naderi Nabi B, Farzi F, Atamanesh H, et al. Comparing the effects of morphine sulfate and diclofenac suppositories on postoperative pain in coronary artery bypass graft patients. Anesth Pain Med. 2014; 4(4)[DOI][PubMed]
  • 3. Mao J, Sung B, Ji RR, Lim G. Chronic morphine induces downregulation of spinal glutamate transporters: implications in morphine tolerance and abnormal pain sensitivity. J Neurosci. 2002; 22(18): 8312-23[PubMed]
  • 4. Dahi-Taleghani M, Fazli B, Ghasemi M, Vosoughian M, Dabbagh A. Effect of intravenous patient controlled ketamine analgesiaon postoperative pain in opium abusers. Anesth Pain Med. 2014; 4(1)[DOI][PubMed]
  • 5. Imani F, Faiz HR, Sedaghat M, Hajiashrafi M. Effects of adding ketamine to fentanyl plus acetaminophen on postoperative pain by patient controlled analgesia in abdominal surgery. Anesth Pain Med. 2014; 4(1)[DOI][PubMed]
  • 6. Imani F, Rahimzadeh P, Faiz SH. Comparison of the efficacy of adding clonidine, chlorpromazine, promethazine, and midazolam to morphine pumps in postoperative pain control of addicted patients. Anesth Pain Med. 2011; 1(1): 10-4[DOI][PubMed]
  • 7. Ebrahimzadeh MH, Mousavi SK, Ashraf H, Abubakri R, Birjandinejad A. Transdermal fentanyl patches versus patient-controlled intravenous morphine analgesia for postoperative pain management. Iran Red Crescent Med J. 2014; 16(5)[DOI][PubMed]
  • 8. Lee RM, Lim Tey JB, Chua NH. Postoperative pain control for total knee arthroplasty: continuous femoral nerve block versus intravenous patient controlled analgesia. Anesth Pain Med. 2012; 1(4): 239-42[DOI][PubMed]
  • 9. Gutstein HB, Akil H. Opioid Analgesics. Opioid agonist/antagonist and partial agonists Goodman & Gilman’s-The pharmacological basis of therapeutics. 2006; : 574-6
  • 10. Clay GA, Brougham LR. Haloperidol binding to an opiate receptor site. Biochem Pharmacol. 1975; 24(13-14): 1363-7[PubMed]
  • 11. Creese I, Feinberg AP, Snyder SH. Butyrophenone influences on the opiate receptor. Eur J Pharmacol. 1976; 36(1): 231-5[PubMed]
  • 12. Lal H, Numan R. Blockade of morphine-withdrawal body shakes by haloperidol. Life Sci. 1976; 18(2): 163-7[PubMed]
  • 13. Lal H, Puri S, Karkalas Y. Blockade of opioid-withdrawal symptoms by haloperidol in rats and humans. Pharmacologist. 1971; 13(2): 263
  • 14. Raft D, Toomey T, Gregg JM. Behavior modification and haloperidol in chronic facial pain. South Med J. 1979; 72(2): 155-9[PubMed]
  • 15. Fishbain DA, Cutler RB, Lewis J, Cole B, Rosomoff RS, Rosomoff HL. Do the second-generation "atypical neuroleptics" have analgesic properties? A structured evidence-based review. Pain Med. 2004; 5(4): 359-65[DOI][PubMed]
  • 16. Seidel S, Aigner M, Ossege M, Pernicka E, Wildner B, Sycha T. Antipsychotics for acute and chronic pain in adults. J Pain Symptom Manage. 2010; 39(4): 768-78[DOI][PubMed]
  • 17. Hanks GW. Psychotropic drugs. Postgrad Med J. 1984; 60(710): 881-5[PubMed]
  • 18. Patt RB, Proper G, Reddy S. The neuroleptics as adjuvant analgesics. J Pain Symptom Manage. 1994; 9(7): 446-53[PubMed]
  • 19. Head M, Lal H, Puri S, Mantione C, Valentino D. Enhancement of morphine analgesia after acute and chronic haloperidol. Life Sci. 1979; 24(22): 2037-43[PubMed]
  • 20. Rooney KF, Sewell RD. Evaluation of selective actions of dopamine D-1 and D-2 receptor agonists and antagonists on opioid antinociception. Eur J Pharmacol. 1989; 168(3): 329-36[PubMed]
  • 21. Karkalas J, Lal H. A comparison of haloperidol with methadone in blocking heroin-withdrawal symptoms. A pilot study. Int Pharmacopsychiatry. 1973; 8(4): 248-51[PubMed]
  • 22. Karkalas Y, Lal H. Haloperidol In Treatment Of Opioid Addiction. 1972; : 10016
  • 23. Saarne A. Experiences with haloperidol (Haldol) as a premedicant. Acta Anaesthesiol Scand. 1963; 7: 21-30[PubMed]
  • 24. Maltbie AA, Cavenar JJ, Sullivan JL, Hammett EB, Zung WW. Analgesia and haloperidol: a hypothesis. J Clin Psychiatry. 1979; 40(7): 323-6[PubMed]
  • 25. Judkins KC, Harmer M. Haloperidol as an adjunct analgesic in the management of postoperative pain. Anaesthesia. 1982; 37(11): 1118-20[PubMed]
  • 26. Honkaniemi J, Liimatainen S, Rainesalo S, Sulavuori S. Haloperidol in the acute treatment of migraine: a randomized, double-blind, placebo-controlled study. Headache. 2006; 46(5): 781-7[DOI][PubMed]
  • 27. Hagelberg N, Jaaskelainen SK, Martikainen IK, Mansikka H, Forssell H, Scheinin H, et al. Striatal dopamine D2 receptors in modulation of pain in humans: a review. Eur J Pharmacol. 2004; 500(1-3): 187-92[DOI][PubMed]
  • 28. Hagelberg N, Martikainen IK, Mansikka H, Hinkka S, Nagren K, Hietala J, et al. Dopamine D2 receptor binding in the human brain is associated with the response to painful stimulation and pain modulatory capacity. Pain. 2002; 99(1-2): 273-9[PubMed]
  • 29. Gear RW, Lee JS, Miaskowski C, Gordon NC, Paul SM, Levine JD. Neuroleptics antagonize nalbuphine antianalgesia. J Pain. 2006; 7(3): 187-91[DOI][PubMed]
  • 30. Ebneshahidi A, Akbari M, Mohseni M. Intraoperative haloperidol does not improve quality of recovery and postoperative analgesia. Adv Biomed Res. 2013; 2: 85[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments