Shiraz E-Medical Journal

Published by: Kowsar

Influence of Sleep Deprivation on the 24-Hour Ghrelin Secretion Pattern

Parvin Zareian 1 , * , Seyed Reza Abtahi 2 and Morteza Nazari Serenjeh 1
Authors Information
1 Department of Physiology, AJA University of Medical Science, Tehran, Iran
2 Department of Pharmacology, AJA University of Medical Sciences, Tehran, Iran
Article information
  • Shiraz E-Medical Journal: October 2018, 19 (10); e66327
  • Published Online: September 5, 2018
  • Article Type: Research Article
  • Received: January 15, 2018
  • Revised: August 11, 2018
  • Accepted: August 18, 2018
  • DOI: 10.5812/semj.66327

To Cite: Zareian P , Abtahi S R, Nazari Serenjeh M. Influence of Sleep Deprivation on the 24-Hour Ghrelin Secretion Pattern, Shiraz E-Med J. 2018 ; 19(10):e66327. doi: 10.5812/semj.66327.

Copyright © 2018, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Methods
3. Results
4. Discussion
  • 1. Langendonk JG, Pijl H, Toornvliet AC, Burggraaf J, Frolich M, Schoemaker RC, et al. Circadian rhythm of plasma leptin levels in upper and lower body obese women: influence of body fat distribution and weight loss. J Clin Endocrinol Metab. 1998;83(5):1706-12. doi: 10.1210/jcem.83.5.4717. [PubMed: 9589680].
  • 2. Ruis MA, Te Brake JH, Engel B, Ekkel ED, Buist WG, Blokhuis HJ, et al. The circadian rhythm of salivary cortisol in growing pigs: effects of age, gender, and stress. Physiol Behav. 1997;62(3):623-30. [PubMed: 9272674].
  • 3. Quabbe HJ, Gregor M, Bumke-Vogt C, Hardel C. Pattern of plasma cortisol during the 24-hour sleep/wake cycle in the rhesus monkey. Endocrinology. 1982;110(5):1641-6. doi: 10.1210/endo-110-5-1641. [PubMed: 7075533].
  • 4. Lazreg TB, Zaouali M, Chaieb M, Dallel N, Chaieb L, Tabka Z, et al. Circadian leptin, insulin and cortisol rhythms in obese subjects. Biol Rhythm Res. 2007;38(1):9-17. doi: 10.1080/09291010600831380.
  • 5. Morris CJ, Aeschbach D, Scheer FA. Circadian system, sleep and endocrinology. Mol Cell Endocrinol. 2012;349(1):91-104. doi: 10.1016/j.mce.2011.09.003. [PubMed: 21939733]. [PubMed Central: PMC3242827].
  • 6. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999;402(6762):656-60. doi: 10.1038/45230. [PubMed: 10604470].
  • 7. Tschop M, Smiley DL, Heiman ML. Ghrelin induces adiposity in rodents. Nature. 2000;407(6806):908-13. doi: 10.1038/35038090. [PubMed: 11057670].
  • 8. Shintani M, Ogawa Y, Ebihara K, Aizawa-Abe M, Miyanaga F, Takaya K, et al. Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway. Diabetes. 2001;50(2):227-32. [PubMed: 11272130].
  • 9. Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes. 2001;50(8):1714-9. [PubMed: 11473029].
  • 10. Tschop M, Wawarta R, Riepl RL, Friedrich S, Bidlingmaier M, Landgraf R, et al. Post-prandial decrease of circulating human ghrelin levels. J Endocrinol Invest. 2001;24(6):RC19-21. doi: 10.1007/BF03351037. [PubMed: 11434675].
  • 11. Asakawa A, Inui A, Kaga T, Yuzuriha H, Nagata T, Fujimiya M, et al. A role of ghrelin in neuroendocrine and behavioral responses to stress in mice. Neuroendocrinology. 2001;74(3):143-7. doi: 10.1159/000054680. [PubMed: 11528215].
  • 12. Leproult R, Van Cauter E. Role of sleep and sleep loss in hormonal release and metabolism. Endocr Dev. 2010;17:11-21. doi: 10.1159/000262524. [PubMed: 19955752]. [PubMed Central: PMC3065172].
  • 13. Natalucci G, Riedl S, Gleiss A, Zidek T, Frisch H. Spontaneous 24-h ghrelin secretion pattern in fasting subjects: maintenance of a meal-related pattern. Eur J Endocrinol. 2005;152(6):845-50. doi: 10.1530/eje.1.01919. [PubMed: 15941923].
  • 14. Moshtaghi-Kashanian GR, Mirzaee F, Khalilzadeh SH. Circadian rhythm of acylated ghrelin, leptin, growth hormone, IGF-1, IGFBP-1 and IGFBP-3. Int J Endocrinol Metab. 2011;9(4):352-9. doi: 10.5812/Kowsar.1726913X.3334.
  • 15. Pruessner JC, Kirschbaum C, Meinlschmid G, Hellhammer DH. Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change. Psychoneuroendocrinology. 2003;28(7):916-31. [PubMed: 12892658].
  • 16. Ulhoa MA, Marqueze EC, Burgos LG, Moreno CR. Shift work and endocrine disorders. Int J Endocrinol. 2015;2015:826249. doi: 10.1155/2015/826249. [PubMed: 25892993]. [PubMed Central: PMC4393906].
  • 17. Potter GD, Cade JE, Grant PJ, Hardie LJ. Nutrition and the circadian system. Br J Nutr. 2016;116(3):434-42. doi: 10.1017/S0007114516002117. [PubMed: 27221157]. [PubMed Central: PMC4930144].
  • 18. Scheer FA, Hilton MF, Mantzoros CS, Shea SA. Adverse metabolic and cardiovascular consequences of circadian misalignment. Proc Natl Acad Sci U S A. 2009;106(11):4453-8. doi: 10.1073/pnas.0808180106. [PubMed: 19255424]. [PubMed Central: PMC2657421].
  • 19. Miyauchi F, Sekihara H. Effect of the night shift work on disturbing the circadian rhythm of cortisol, corticosterone and DHEA in female nurses. The Endocrine Society's 95th Annual Meeting and Expo, June 15–18, 2013. San Francisco. 2013.
  • 20. Bagnasco M, Kalra PS, Kalra SP. Ghrelin and leptin pulse discharge in fed and fasted rats. Endocrinology. 2002;143(2):726-9. doi: 10.1210/endo.143.2.8743. [PubMed: 11796530].
  • 21. Barkan AL, Dimaraki EV, Jessup SK, Symons KV, Ermolenko M, Jaffe CA. Ghrelin secretion in humans is sexually dimorphic, suppressed by somatostatin, and not affected by the ambient growth hormone levels. J Clin Endocrinol Metab. 2003;88(5):2180-4. doi: 10.1210/jc.2002-021169. [PubMed: 12727973].
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