Benefits of Metformin Combined with Insulin in Children with Type 1 Diabetes Mellitus.


Z Abdeyazdan 1 , * , M Hashemipour 2 , R Barekatain 3 , F Kalantary 4 , M Amini 4

1 Associate Professor, Nursing and Midwifery Care Research Center, Faculty of Nursing and Midwifery,

2 Professor, Department of Pediatrics, School of Medicine,

3 Pediatrician, Endocrine and Metabolism Research Center,

4 Nurse, Endocrine and Metabolism Research Center, ? Professor, Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

How to Cite: Abdeyazdan Z, Hashemipour M, Barekatain R, Kalantary F, Amini M. Benefits of Metformin Combined with Insulin in Children with Type 1 Diabetes Mellitus., Shiraz E-Med J. Online ahead of Print ; 12(4):167-71.


Shiraz E-Medical Journal: 12 (4); 167-71
Published Online: October 1, 2011
Article Type: Research Article
Received: August 10, 2010
Accepted: August 22, 2011




Background: Some patients with type 1 diabetes mellitus have not good glycaemic control with ordinary doses of insulin. So applying other treatment modality in addition to insulin and diet therapy could improve glycaemic control.

Objective: To evaluate whether, in patients with type 1 diabetes mellitus, the addition of Metformin to insulin and standard diabetes management result in better glycaemic control and lower insulin dosage .

Methods: In a clinical trial study 16 children and adolescents with type 1 diabetes with had high insulin intake and HbA1c >8% were participated. HbA1c, FBS, 2hpp BG, insulin dosage and BMI were measured and compared at the onset and end of the treatment.

Results: There were significant differences in HbA1c and insulin dosage between the time of 0 of the study and after 4 months of Metformin addition therapy. But there were no significant differences between BMI, FBG and 2 h pp BG at the onset of the study and end of it.

Conclusion: Metformin treatment lowered HbA1c and decreased insulin dosage in patients with type 1 diabetes in poor metabolic control. Long term studies will determine if these improvements are sustained.


Type 1 diabetes mellitus Metformin HbA1c Fasting Blood Sugar

© 2011, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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