Familial Mediterranean Fever

AUTHORS

M Haghighat * , +

How to Cite: Haghighat M. Familial Mediterranean Fever, Shiraz E-Med J. Online ahead of Print ; 7(2):20368.

ARTICLE INFORMATION

Shiraz E-Medical Journal: 7 (2); 1-18
Published Online: April 1, 2006
Article Type: Review Article

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Abstract

Familial Mediterranean Fever (FMF) or recurrent polyserositis is an inherited multisystem disease manifested by recurrent painful attacks affecting the abdomen, chest or joints, often accompanied by fever and sometimes a skin rash. FMF is a genetic condition, inherited in an autosomal recessive fashions. FMF could be described as a disorder of inappropriate inflammation of one or more of serusal membrane (serositis). The diagnosis of FMF is generally based on the clinical criteria although the direct analysis of MEFV gene is the only method to be certain of the disease. The goals of therapy are to reduce the morbidity and prevent complications of the disease, which is consists of taking colchicine, a neutrophil suppresisive agent. Since FMF is a genetic disease, it can be prevented only if the carriers of the defective gene are identified.

Keywords

Familial Mediterranean Fever, Clinical Presentation, Diagnosis, Treatment and Prevention

© 2006, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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