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Preliminary Report of Interferon ?2b in Combination with Ribavirin for 48 Weeks for Treatment of Iranian Patients with Chronic Hepatitis C: a Quasi-Experimental Study

AUTHORS

SM Alavian 1 , * , A Kabir 2 , B Hajarizadeh 3 , M Nayebpour 4 , T Dorodi 3 , FE Baralle 5

1 Associate professor; Department Medicine, Section of Gastroenterology, Baghiatollah University of Medical Sciences; Dean of Tehran Hepatitis Center, Tehran, Iran

2 Methodology and statistics consultant; Tehran Hepatitis Center, Tehran, Iran

3 Research Fellow, Tehran Hepatitis Center, Tehran, Iran

4 Assistant professor of pharmacology, Faculty of pharmacy, Tehran University of Medical Sciences, Tehran, Iran

5 Professor and Director of International Center for Genetic Engineering and Biotechnology, Trieste, Italy

How to Cite: Alavian S, Kabir A, Hajarizadeh B, Nayebpour M, Dorodi T, et al. Preliminary Report of Interferon ?2b in Combination with Ribavirin for 48 Weeks for Treatment of Iranian Patients with Chronic Hepatitis C: a Quasi-Experimental Study, Shiraz E-Med J. Online ahead of Print ; 7(1):20390.

ARTICLE INFORMATION

Shiraz E-Medical Journal: 7 (1); 1-8
Published Online: January 1, 2006
Article Type: Research Article

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Abstract

Aim: The addition of ribavirin (RIBA) to the standard treatment with interferon (IFN) alpha led to an improvement in sustained virologic response (SVR) from less than 20% with IFN monotherapy to 40-45% in combination therapy. The aim of this study is to assess the therapeutic efficacy and safety of IFN alpha (PDferon) in combination with RIBA on Iranian patients with chronic hepatitis C (CHC).

Methods: 48 naive patients aged 18 years or more with CHC were enrolled and treated with 3 mega units (MU) IFN ?-2b three times a week plus 600-1000 mg RIBA per day for 48 weeks. Follow-up after therapy was 6 months. The efficacy was evident at the end of treatment and at the end of follow-up in terms of sustained normalization of alanine aminotransferase and sustained serum HCV-RNA loss.

results: The rate of sustained biochemical and virologic response were 68.3% and 78%, respectively. 40 patients (83.3%) had at least one not serious complication and 8 patients (16.7%) didnt have any complication. Any patient didnt have serious complication.

conclusion: Although we had no control group who used standard IFN, our preliminary finding showed acceptable and promising response rate of PDferon. On the other hand, it seems that adverse events with PDferon are as like as other standard IFNs.

Keywords

Interferon, Ribavirin, Hepatitis C, Treatment

© 2006, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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