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Familial Inheritance in Diabetes Mellitus in South Iranian Population

AUTHORS

MA Ostovan 1 , *

1 Assistant Professor, Section of Cardiology, Department of Internal Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

How to Cite: Ostovan M. Familial Inheritance in Diabetes Mellitus in South Iranian Population, Shiraz E-Med J. Online ahead of Print ; 8(4):151-154.

ARTICLE INFORMATION

Shiraz E-Medical Journal: 8 (4); 151-154
Published Online: October 1, 2007
Article Type: Research Article
Received: February 11, 2007
Accepted: June 29, 2007

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Abstract

Background: Diabetes Mellitus (DM), the most common endocrine disease, is characterized by metabolic abnormalities and by its long term complications. It is well known that genetic predisposition is an important factor in occurrence of diabetes mellitus but the mechanism of inheritance of this disorder is unclear. The more significance of maternal or paternal inheritance in diabetes has been a matter of controversy and difference in various populations and races, so this study was conducted to evaluate pattern of inheritances in Fars diabetes center referrals as a Southern Iranian population.

Materials and Methods: In this study 1056 diabetic patients in Fars diabetes center were interviewed by trained interviewers using a standard questionnaire and information about family history of 1st and 2nd degree relatives of patients were recorded.

Results: In this study type II diabetes had more familial aggregation than type I diabetes (p <0.001). Maternal transmission of diabetes was stronger in type II diabetes than type I (p<0.001). Positive family history of diabetes in 2nd degree relative of type I patients was significantly more common that type II diabetic patients (P<0.001). Maternal history of diabetes is stronger than paternal history of diabetes among both type I and type II diabetic populations (type I P<0.05 and type II P<0.001).

Keywords

diabetes mellitus, family history, gene.

© 2007, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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