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Role of N-Acetylglucosamine in Ca2+ and Mg2+ ions- regulated Fila- mentous Growth and Protein Glycosylation in C. albicans

AUTHORS

M ER-RASFA 1 , *

1 Associate Professor, Laboratory of Pharmacology, Faculty of medicine and pharmacy, University of sidi Mohamed Ben Abdellah, Fez, Morocco

How to Cite: ER-RASFA M. Role of N-Acetylglucosamine in Ca2+ and Mg2+ ions- regulated Fila- mentous Growth and Protein Glycosylation in C. albicans, Shiraz E-Med J. Online ahead of Print ; 9(2):57-67.

ARTICLE INFORMATION

Shiraz E-Medical Journal: 9 (2); 57-67
Published Online: April 1, 2008
Article Type: Research Article
Received: September 19, 2007
Accepted: February 15, 2008

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Abstract

Glucose or N-Acetylglucosamine induce similar filamentous growth and a specific calcium and magnesium-dependent intracellular glycoprotein pattern in C. albicans at 37 C in vitro. Both filament growth and its associated glycoprotein pattern are inhibited by calcium ions. The above inhibition can be reversed by magnesium ions, though only in N-Acetylglucosamine- but not in glucose-treated cells. Our data show that in contrast to glucose, N-Acetylglucosamine more than being only a carbon source, it is a key factor for filamentous growth and intracellu- lar protein glycosylation to occur, and thus, it may effect the interaction of C. albicans with its host in a calcium- and magnesium-dependent manner.

Keywords

C.albicans, filamentous growth, glycosylation, mannoproteins, N-Acetyl Glucosamine.

© 2008, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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