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Advantages of Buprenorphine in Comparison to Morphine in Postoperative Pain Control

AUTHORS

M Jafari Javid 1 , * , M Ghanbar 1 , A Shahidi 2 , Sh Golbabaii 1 , S Atashkhoii 3 , Sh Shahrokhi 4

1 Assistant Professor, Department of Anesthesiology, Tehran University of Medical Sciences, Tehran, Iran

2 General Medical Practitioner, Tehran, Iran

3 Associate Professor, Department of Anesthesiology, Tabriz University of Medical Sciences, Tabriz, Iran

4 Resident, Department of Anesthesiology, Tehran University of Medical Sciences, Tehran, Iran

How to Cite: Jafari Javid M, Ghanbar M, Shahidi A, Golbabaii S, Atashkhoii S, et al. Advantages of Buprenorphine in Comparison to Morphine in Postoperative Pain Control, Shiraz E-Med J. Online ahead of Print ; 9(3):129-133.

ARTICLE INFORMATION

Shiraz E-Medical Journal: 9 (3); 129-133
Published Online: July 1, 2008
Article Type: Research Article
Received: October 18, 2007
Accepted: January 27, 2008

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Abstract

Introduction: Pre-emptive analgesia has been used widely and effectively for post operative pain relief. In this study Bupernorphine, a partial agonist of opioids has been compared to Morphine as preemptive analgesic with the aim to achieve better pain control and less post operative complications.

Materials and Methods: In this randomized double blind clinical trial, 60 patients were assigned in two equal groups of study (each group=30). Bupernorphine group received 4mcg/kg IV of the drug and morphine group received 0.1mg/kgIV of the drug, 10 minutes before induction of anesthesia. The average time of the first demand for post operative analgesic, the frequencies of demands and the total amount of administered analgesics were recorded. The incidence of post operative complications such as respiratory depression and postoperative nausea and vomiting (PONV) were recorded.

Results: The average time of the first demand for analgesic in Bupernorphine group (41020minutes) was significantly longer than morphine group (24025minutes), p<0.0001. The number of patients demanded analgesic were lower in Bupernorphine group (46.7%) than morphine group (90%), p<0.0001. The average increase in arterial paco2 was higher in Morphine group. No significant differences were noted between two groups in the incidence of post operative shivering and Nausea and vomiting.

Conclusion: Intravenous Bupernorphine before induction of anesthesia was more effective and had fewer side effects than morphine in post operative pain management.

Keywords

Preemptive analgesia, Bupernorphine, Morphine PONV, Abdominal surgery.

© 2008, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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