Shiraz E-Medical Journal

Published by: Kowsar
Crossmark

In Vivo Assay of Wound Healing Activities of Silymarin Extract on Cutaneous Wounds Caused by Leishmania major

Mohammad Rastegarian 1 , Zahra Ghanbarinasab 1 , Roham Borazjani 1 , Mahnaz Hosseini 1 , Shiva Aminnia 1 , Soheil Ashkani-Esfahani 1 , * , Qasem Asgari 2 and Bahador Sarkari 3
Authors Information
1 Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
2 Department of Parasitology and Mycology, Shiraz University of Medical Sciences, Shiraz, Iran
3 Basic Sciences in Infectious Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Article information
  • Shiraz E-Medical Journal: 20 (3); e79229
  • Published Online: December 4, 2018
  • Article Type: Research Article
  • Received: May 19, 2018
  • Revised: September 21, 2018
  • Accepted: September 24, 2018
  • DOI: 10.5812/semj.79229

To Cite: Rastegarian M, Ghanbarinasab Z, Borazjani R, Hosseini M, Aminnia S, et al. In Vivo Assay of Wound Healing Activities of Silymarin Extract on Cutaneous Wounds Caused by Leishmania major, Shiraz E-Med J. Online ahead of Print ; 20(3):e79229. doi: 10.5812/semj.79229.

Abstract
Copyright © 2018, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Methods
4. Results
5. Discussion
Acknowledgements
Footnotes
References
  • 1. Croft SL, Coombs GH. Leishmaniasis-current chemotherapy and recent advances in the search for novel drugs. Trends Parasitol. 2003;19(11):502-8. [PubMed: 14580961].
  • 2. Alvar J, Velez ID, Bern C, Herrero M, Desjeux P, Cano J, et al. Leishmaniasis worldwide and global estimates of its incidence. PLoS One. 2012;7(5). e35671. doi: 10.1371/journal.pone.0035671. [PubMed: 22693548]. [PubMed Central: PMC3365071].
  • 3. Desjeux P. Leishmaniasis: Current situation and new perspectives. Comp Immunol Microbiol Infect Dis. 2004;27(5):305-18. doi: 10.1016/j.cimid.2004.03.004. [PubMed: 15225981].
  • 4. Farahmand M, Nahrevanian H, Shirazi HA, Naeimi S, Farzanehnejad Z. An overview of a diagnostic and epidemiologic reappraisal of cutaneous leishmaniasis in Iran. Braz J Infect Dis. 2011;15(1):17-21. [PubMed: 21412584].
  • 5. Tiuman TS, Santos AO, Ueda-Nakamura T, Filho BP, Nakamura CV. Recent advances in leishmaniasis treatment. Int J Infect Dis. 2011;15(8):e525-32. doi: 10.1016/j.ijid.2011.03.021. [PubMed: 21605997].
  • 6. Hadighi R, Mohebali M, Boucher P, Hajjaran H, Khamesipour A, Ouellette M. Unresponsiveness to Glucantime treatment in Iranian cutaneous leishmaniasis due to drug-resistant Leishmania tropica parasites. PLoS Med. 2006;3(5). e162. doi: 10.1371/journal.pmed.0030162. [PubMed: 16605301]. [PubMed Central: PMC1435779].
  • 7. Croft SL, Sundar S, Fairlamb AH. Drug resistance in leishmaniasis. Clin Microbiol Rev. 2006;19(1):111-26. doi: 10.1128/CMR.19.1.111-126.2006. [PubMed: 16418526]. [PubMed Central: PMC1360270].
  • 8. Singh RP, Tyagi AK, Zhao J, Agarwal R. Silymarin inhibits growth and causes regression of established skin tumors in SENCAR mice via modulation of mitogen-activated protein kinases and induction of apoptosis. Carcinogenesis. 2002;23(3):499-510. [PubMed: 11895866].
  • 9. Katiyar SK. Treatment of silymarin, a plant flavonoid, prevents ultraviolet light-induced immune suppression and oxidative stress in mouse skin. Int J Oncol. 2002;21(6):1213-22. doi: 10.3892/ijo.21.6.1213.
  • 10. Ramakrishnan G, Raghavendran HR, Vinodhkumar R, Devaki T. Suppression of N-nitrosodiethylamine induced hepatocarcinogenesis by silymarin in rats. Chem Biol Interact. 2006;161(2):104-14. doi: 10.1016/j.cbi.2006.03.007. [PubMed: 16643877].
  • 11. Nencini C, Giorgi G, Micheli L. Protective effect of silymarin on oxidative stress in rat brain. Phytomedicine. 2007;14(2-3):129-35. doi: 10.1016/j.phymed.2006.02.005. [PubMed: 16638633].
  • 12. Schumann J, Prockl J, Kiemer AK, Vollmar AM, Bang R, Tiegs G. Silibinin protects mice from T cell-dependent liver injury. J Hepatol. 2003;39(3):333-40. [PubMed: 12927918].
  • 13. Toklu HZ, Tunali-Akbay T, Erkanli G, Yuksel M, Ercan F, Sener G. Silymarin, the antioxidant component of Silybum marianum, protects against burn-induced oxidative skin injury. Burns. 2007;33(7):908-16. doi: 10.1016/j.burns.2006.10.407. [PubMed: 17521818].
  • 14. Ashkani-Esfahani S, Emami Y, Esmaeilzadeh E, Bagheri F, Namazi MR, Keshtkar M, et al. Silymarin enhanced fibroblast proliferation and tissue regeneration in full thickness skin wounds in rat models; a stereological study. J Saudi Soc Dermatol Dermatol Surg. 2013;17(1):7-12. doi: 10.1016/j.jssdds.2012.11.001.
  • 15. Ashkani-Esfahani S, Zarifi F, Asgari Q, Samadnejad AZ, Rafiee S, Noorafshan A. Taurine improves the wound healing process in cutaneous leishmaniasis in mice model, based on stereological parameters. Adv Biomed Res. 2014;3:204. doi: 10.4103/2277-9175.142314. [PubMed: 25337534]. [PubMed Central: PMC4202507].
  • 16. Ashkani-Esfahani S, Emami Y, Esmaeilzadeh E, Bagheri F, Namazi MR. Glucosamine enhances tissue regeneration in the process of wound healing in rats as animal model: A stereological study. J Cytol Histol. 2012;3:150. doi: 10.4172/2157-7099.1000150.
  • 17. Gupta OP, Sing S, Bani S, Sharma N, Malhotra S, Gupta BD, et al. Anti-inflammatory and anti-arthritic activities of silymarin acting through inhibition of 5-lipoxygenase. Phytomedicine. 2000;7(1):21-4. doi: 10.1016/S0944-7113(00)80017-3. [PubMed: 10782486].
  • 18. Calixto JB, Otuki MF, Santos AR. Anti-inflammatory compounds of plant origin. Part I. Action on arachidonic acid pathway, nitric oxide and nuclear factor kappa B (NF-kappaB). Planta Med. 2003;69(11):973-83. doi: 10.1055/s-2003-45141. [PubMed: 14735432].
  • 19. Middleton EJ, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer. Pharmacol Rev. 2000;52(4):673-751. [PubMed: 11121513].
  • 20. Kang JS, Jeon YJ, Kim HM, Han SH, Yang KH. Inhibition of inducible nitric-oxide synthase expression by silymarin in lipopolysaccharide-stimulated macrophages. J Pharmacol Exp Ther. 2002;302(1):138-44. [PubMed: 12065710].
  • 21. Katiyar SK. Silymarin and skin cancer prevention: Anti-inflammatory, antioxidant and immunomodulatory effects. Int J Oncol. 2005;26(1):169-76. doi: 10.3892/ijo.26.1.169.
  • 22. Altaei TS, Numan IT, Hussain SA, Al-Talabani NG. The efficacy of topically applied silymarin in the treatment of herpes labialis ulcers. Iraqi J Pharm Sci. 2007;16(1):39-46.
  • 23. Marchiori MCL, Rigon C, Camponogara C, Oliveira SM, Cruz L. Hydrogel containing silibinin-loaded pomegranate oil based nanocapsules exhibits anti-inflammatory effects on skin damage UVB radiation-induced in mice. J Photochem Photobiol B. 2017;170:25-32. doi: 10.1016/j.jphotobiol.2017.03.015. [PubMed: 28365493].
  • 24. Mady FM, Essa H, El-Ammawi T, Abdelkader H, Hussein AK. Formulation and clinical evaluation of silymarin pluronic-lecithin organogels for treatment of atopic dermatitis. Drug Des Devel Ther. 2016;10:1101-10. doi: 10.2147/DDDT.S103423. [PubMed: 27022248]. [PubMed Central: PMC4790491].
  • 25. Feher P, Ujhelyi Z, Varadi J, Fenyvesi F, Roka E, Juhasz B, et al. Efficacy of pre-and post-treatment by topical formulations containing dissolved and suspended silybum marianum against UVB-induced oxidative stress in guinea pig and on HaCaT keratinocytes. Molecules. 2016;21(10). doi: 10.3390/molecules21101269. [PubMed: 27669200].
  • 26. Jabini R, Jaafari MR, Vahdati Hasani F, Ghazizadeh F, Khamesipour A, Karimi G. Effects of combined therapy with silymarin and glucantime on leishmaniasis induced by Leishmania major in BALB/c mice. Drug Res (Stuttg). 2015;65(3):119-24. doi: 10.1055/s-0034-1370914. [PubMed: 24623031].
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:

Author(s):

Article(s):

Create Citiation Alert
via Google Reader

Readers' Comments