Occult HBV Infection among Chronic Hepatitis C Patients

AUTHORS

R Aghazadeh 1 , Honarkar 2 , * , SM Alavian 3 , Sh Samiee 4 , K Saeedfar 5 , M Baladast 5 , MJ Ehsani 1 , AH Mohammadali Zadeh 6 , A Nori Nayer 6 , MR Zali 7

1 Department of Gastroenterology, Taleghani Hospital, Tehran, Iran

2 Gastroenterologist, Research Center for Gastroenterology and Liver Disease, Shaheed Beheshti University of Medical Sciences, Tehran, Iran

3 Associate Professor of Gastroenterology, Department of Internal Medicine, Baqiatollah Medical University; Head of Tehran Hepatitis Center, Tehran, Iran

4 Iran Blood Transfusion Organization, Tehran, Iran

5 Research Fellow, Research Center for Gastroenterology and Liver Disease, Shaheed Beheshti University of Medical Sciences, Tehran, Iran

6 Assistant Professor of Gastroenterology, Department of Gastroenterology, Taleghani Hospital, Tehran, Iran

7 Professor of Gastroenterology, Department of Gastroenterology, Taleghani Hospital, Head of Research Center of Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran

How to Cite: Aghazadeh R, Honarkar , Alavian S, Samiee S, Saeedfar K, et al. Occult HBV Infection among Chronic Hepatitis C Patients, Shiraz E-Med J. Online ahead of Print ; 7(2):20372.

ARTICLE INFORMATION

Shiraz E-Medical Journal: 7 (2); 1-6
Published Online: April 1, 2006
Article Type: Research Article

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Abstract

Transmission routs of both hepatitis B and hepatitis C viruses are similar and infection with both viruses is common. Occult hepatitis B is a new entity in which serum HBsAg is negative but HBVDNA is detectable in serum or liver tissues. In this study the frequency of occult hepatitis B among patients with chronic hepatitis C and also their biochemical and histological changes were investigated. In this study, 27 patients with chronic hepatitis C with negative serum HBsAg were enrolled. These patients had been referred to Taleghani hospital and RCGLD (Research Center for Gastroenterology and Liver Diseases) or THC (Tehran Hepatitis Center) during years 2001 and 2002 and had been undertaken liver biopsy. Liver biopsies were reviewed and hepatitis B virus (HBV) DNA and HBsAg and HBcAg were assayed in liver tissue by polymerase chain reaction (PCR) and immunohistochemistry (IHC) respectively. From 27 chronic hepatitis C patients studied, HBVDNA was detectable by PCR in 5(19%). Immunohistochemistry for both HBcAg and HBsAg were reported to be negative in all patients. Histological changes of cirrhosis and symptoms of decompensated cirrhosis were seen just in HBVDNA positive patients. This study concludes that Occult HBV infection is common among chronic hepatitis C patients. Occult hepatitis B probably accelerates the evolution to cirrhosis in patients with chronic hepatitis C.

Keywords

Chronic hepatitis B, Chronic hepatitis C, Chronic liver diseases, HBVDNA

© 2006, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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