Microabuminuria in Type 1 Diabetes Mellitus

AUTHORS

Z Abdeyazdan 1 , * , M Hashemipour 2 , A Hasanzadeh 3 , Z Pour Naghshban 4 , M Kabirzadeh 5

1 Assistant Professor, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran

2 Professor, Department of Pediatrics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3 Lecturer, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran

4 Laboratory Assistant, Endocrine and Metabolism Research Center, Isfahan, Iran

5 Research Assistant, Endocrine and Metabolism Research Center, Isfahan, Iran

How to Cite: Abdeyazdan Z, Hashemipour M, Hasanzadeh A, Pour Naghshban Z, Kabirzadeh M. Microabuminuria in Type 1 Diabetes Mellitus, Shiraz E-Med J. Online ahead of Print ; 8(1):28-32.

ARTICLE INFORMATION

Shiraz E-Medical Journal: 8 (1); 28-32
Published Online: January 1, 2007
Article Type: Research Article
Received: January 1, 1970
Accepted: December 25, 2006

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Abstract

Introduction: Nephropathy is one of the risky complications of Type I diabetes mellitus that could lead to end stage renal disease. Persistent microalbuminuria i.e. small amounts of urinary albumin excretion (UAE), is the best predictor of high risk of developing diabetic nephropathy. Early diagnosis of microabminuria and evaluation of patients with this, regarding the presence of comorbid associations are effective strategies for reduction of diabetic mortality and morbidity. The present study carried out because the great variability in prevalence of nephropathy depends on geographic area and different population and little is known about the prevalence of nephropathy and its preceding morbidity in our community.

Aims: To determine the frequency of microabumnuria in children and adolescents with insulin dependent diabetes mellitus.

Subjects and Methods: n a cross sectional study frequency of microalbuminaria was investigated in 39 children and adolescents with IDDM which were selected by simple convenient sampling. Data were analyzed by descriptive inferential method (distribution, frequency rate, mean, standard deviation, t test and x2 test) using SPSS. P value < 0.05 was considered significant.

Results: from a total 39 patients with 5 years duration of diabetes 9(23.1%) patients were microalbuminuric and 30 (76.9%) of them normoalbumminuric. The mean duration of diabetes was 7.882.7 year in microalbuminuric patients and in normoalbuminoric patients was 72.5 year, The age of patients was 16.06 2.3 year in miroalbuminuric group and in normoalbumiric patients it was 13.87 3.41 year (p=0.01). In microalbuminric patients systolic blood pressure and diastolic blood pressure were 10.51 0.98 mm Hg and 6.91.8 mm Hg respectively. In normoalbuminuric patients systolic blood pressure was 10.261.31 mmHg and diastolic pressure 7.1 0.75 mmHg. In patients with microalbuminuria the mean of HbA1c value was 8.442.08 and in normoalbuminuric patients it was 8.621.88. Findings also, showed no association between miroalbuminuria with total cholesterol, HDL LDL and triglyceride.

Discussion: In our study the mean age of patients in microalbuminuric and normoalbuminuric groups was significantly different, so this could be related to ethnic difference in different populations. Based on data obtained, absence of relationship between microalbuminuria and variables may be due to low numbers of samples, also the frequency rate of microalbuminuria in our patients was higher that many other studies. So, we can say this study can be perceived as a pilot study and we suggest doing study on more numbers of patients who are attending in different clinics of diabetes and as a national study.

Keywords

Diabetes Mellitus, Type 1, Proteinurea.

© 2007, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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