Value of Core Needle Biopsy as the First Diagnostic Procedure in the Palpable Breast Masses

AUTHORS

F Karimian 1 , A Aminian 1 , * , E Hashemi 2 , AP Meysamie 3 , R Mirsharifi 4 , A Alibakhshi 1

1 Assistant Professor, Department of General Surgery, Imam Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

2 General Surgeon, Iranian Center for Breast Cancer, Tehran, Iran

3 Assistant Professor of Community Medicine, Tehran University of Medical Sciences, Tehran, Iran

4 Associate Professor, Department of General Surgery, Imam Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

How to Cite: Karimian F, Aminian A, Hashemi E, Meysamie A, Mirsharifi R, et al. Value of Core Needle Biopsy as the First Diagnostic Procedure in the Palpable Breast Masses, Shiraz E-Med J. Online ahead of Print ; 9(4):188-192.

ARTICLE INFORMATION

Shiraz E-Medical Journal: 9 (4); 188-192
Published Online: October 1, 2008
Article Type: Research Article
Received: June 10, 2008
Accepted: August 15, 2008

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Abstract

Background: Breast core needle biopsy (CNB) provides enough tissue for histopathologic diagnosis and is considered a reliable method for establishing preoperative tissue diagnosis. The purpose of this study is to evaluate CNB as the first diagnostic step instead of excisional biopsy in palpable breast masses.

Materials and Methods: In this prospective study, patients with palpable breast mass who underwent CNB were enrolled. Based on pathology report, patients with malignant lesions revealed by CNB were immediately candidate for surgery and those who had benign lesions were followed up to 3 years.

Results: 112 females with palpable breast mass were enrolled in the study. In 103 (91.9%) of cases first attempt CNB provided adequate sample tissue. CNB detected malignant lesion in seventy eight (69.6%) patients. All (100%) malignant CNB reports were confirmed at surgery specimen pathology. In 34 (30.4%) patients CNB revealed benign lesion. At the end of 3 years follow up period, 25 (73%) of these patients underwent open biopsy leading to the detection of 1 (3%) malignant tumor. Overall, according to the gold standard defined as positive surgical biopsy or positive follow-up, sensitivity of CNB was calculated as 98.7% (95% CI, 94.1-100%) and its accuracy was 99.1% (95% CI, 97.4-100%). The specificity of the CNB procedure was 100%.

Conclusion: These findings suggest that the malignancy detection power provided by CNB may be weighed equal to that of open biopsy. Therefore, we propose CNB as the first choice in diagnostic evaluation of palpable breast mass especially for those in accessible sites and in experienced hands.

Keywords

Breast mass, breast cancer, malignancy, biopsy, core needle biopsy

© 2008, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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