Does Pregnancy actually affect serum calcium and inorganic phosphate levels?

AUTHORS

Ikaraoha Chidiebere Ikechukwu 1 , * , Usoro Chinyere A.O 2 , Igwe Chidi Uzoma 3 , Nwobu Gilbert O 3 , Mokogwu Azukaego Thomas Hughs 1 , Okwara John Ekenedirichukwu 4 , Ukaegbu Queeneth O 3

1 Department. of Chemical Pathology, School of Clinical Medicine, Igbinedion University, Okada, Edo State, Nigeria.

2 Department of Chemical Pathology, College of Medicine, University of Calabar, Nigeria.

3 Department. of Medical Laboratory Sciences, College Of Medicine, Ambrose Alli University, Ekpoma, Nigeria.

4 Department of Chemical Pathology, College Medicine, University of Ibadan, Ibadan, Nigeria.

How to Cite: Ikechukwu I C, A.O U C, Uzoma I C, Gilbert O N, Thomas Hughs M A, et al. Does Pregnancy actually affect serum calcium and inorganic phosphate levels? , Shiraz E-Med J. Online ahead of Print ; 6(1 and 2):31836.

ARTICLE INFORMATION

Shiraz E-Medical Journal: 6 (1 and 2); 31836
Published Online: April 4, 2005
Article Type: Research Article
Received: October 14, 2004
Accepted: December 20, 2004

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Abstract

The serum level of calcium and inorganic phosphate in pregnancy is less well defined among Black Nigerians, than among Caucasians. This case control study assessed the relation of serum calcium and inorganic phosphate concentrations to pregnancy in Nigerian women. Blood samples were collected by venepuncture technique from 128 pregnant women during their first, second and third trimesters. A total of 72 non pregnant women were recruited as controls. Serum calcium and inorganic phosphate levels were determined. Pregnant women had significantly lower serum levels of calcium and inorganic phosphate compared to controls (P<0.000 and P<0.001) respectively. There was a statistically significant progressive decrease in serum calcium and inorganic phosphate concentration from first trimester to third trimester (P<0.000 and P<0.001) respectively. Serum calcium and inorganic phosphate may be reduced during pregnancy due to inadequate dietary intake. The decrease in serum calcium and inorganic phosphate levels parallels increase in gestational age. This may result from mineral transfer from mother to developing fetus.

Keywords

Calcium Inorganic phosphate Nigeria Pregnancy Trimester

© 2005, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.

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